Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
(A) DNA fragmentation in freshly isolated islets from 5 (preobese)-, 7 (obese and prediabetic)-, and 14 (diabetic)-week-old fa/fa ZDF rats and lean +/+ controls. Ladder (%), fragmented DNA percent; lane 1, 100-bp DNA size marker (Boeringer Mannheim). (B) Ceramide content in pancreatic islets of obese fa/fa ZDF (solid bars) and lean +/+ controls (open bars). Values are the mean ± SEM of three or four experiments. ∗, P < 0.05 vs. +/+; †, P < 0.05 vs. 7 week.
