TABLE 2.
Quantitative changes in blood and lymphoid systems in PURA genetically altered mice
| PURA mouse type | No. of blood reticulocytesa | Spleen mass (mg) | % Replicating cellsb in:
|
||
|---|---|---|---|---|---|
| Thymic cortex (lymphoid) | Spleen, white pulp (lymphoid) | Spleen, red pulp (myeloid) | |||
| +/+ | 208 ± 27 | 29.2 ± 1.6 | 54.3 ± 2.5 | 11.56 ± 0.71 | 34.4 ± 1.74 |
| +/− | 184 ± 3.5 | 9.27 ± 1.0 | 13.55 ± 3.68 | 27.3 ± 8.06 | |
| −/− | 86 ± 14 | 5.85 ± 0.7 | 8.3 ± 09 | 8.53 ± 1.78 | 3.17 ± 0.66 |
a
Mean number of cells per 10 high-power microscopic fields ± standard deviation.
b
Percentage of cells staining positive for nuclear MCM7.