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Schematic representation of protein receptor-independent activation of G proteins by fluid shear stress. Increase in the rotational and translational mobility in the lipid bilayer and the accompanying decrease in microviscosity activate membrane-bound G proteins by facilitating exchange of GDP for GTP. The intrinsic GTPase activity of the α subunit hydrolyzes GTP to GDP, releasing inorganic phosphate (Pi), and α-GDP recombines with βγ, ending the activation cycle.
