Table 3.
Reasons for withdrawal from WISDOM before 15 July 2002. (Values are numbers (percentages))
| Reasons‡ | Combined therapy v placebo* | Combined therapy v oestrogen therapy† | |||
|---|---|---|---|---|---|
| Combined therapy (n=430) | Placebo (n=203) | Combined therapy (n=88) | Oestrogen therapy (n=78) | ||
| Vaginal bleeding | 122 (28) | 2 (1) | 0 | 0 | |
| Other potentially HRT related symptoms | 94 (22) | 18 (9) | 23 (27) | 14 (18) | |
| Concerns about risks of HRT | 33 (8) | 17 (8) | 8 (9) | 10 (13) | |
| Social (such as moved) | 22 (5) | 24 (12) | 6 (7) | 10 (13) | |
| No longer wished to be in a trial | 16 (4) | 33 (16) | 5 (6) | 1 (1) | |
| Protocol excluded outcome | 22 (5) | 5 (2) | 6 (7) | 2 (3) | |
| Other protocol exclusion | 3 (1) | 3 (1) | 0 | 1 (1) | |
| Cardiac outcome | 5 (1) | 1 (0.5) | 1 (1) | 1 (1) | |
| Cerebrovascular outcome | 2 (0.5) | 6 (3) | 1 (1) | 1 (1) | |
| Menopausal symptoms | 2 (0.5) | 10 (5) | 1 (1) | 1 (1) | |
| Non-trial HRT prescription | 1 (0) | 3 (1) | 3 (3) | 3 (4) | |
| Other diagnoses or symptoms | 103 (24) | 66 (33) | 28 (33) | 30 (38) | |
| Unknown | 5 (1) | 15 (7) | 4 (5) | 2 (3) | |
HRT = hormone replacement therapy.
*Combined therapy = conjugated equine oestrogen 0.625 mg + medroxyprogesterone acetate 2.5 mg orally daily.
†Oestrogen therapy = conjugated equine oestrogen 0.625 mg orally daily.
‡More than one reason may be given.