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. 2007 Feb 27;363(1):48–58. doi: 10.1016/j.virol.2007.01.033

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Copyright © 2007 Elsevier Inc. All rights reserved.

Elsevier has created a Monkeypox Information Center (https://www.elsevier.com/connect/monkeypox-information-center) in response to the declared public health emergency of international concern, with free information in English on the monkeypox virus. The Monkeypox Information Center is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its monkeypox related research that is available on the Monkeypox Information Center - including this research content - immediately available in publicly funded repositories, with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the Monkeypox Information Center remains active.

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Fig. 3 — Protective effects of alveolar macrophages in sublethal vaccinia infection. Mice (n = 10) were injected intratracheally with clodronate or saline liposomes and then infected 2 days later with 4 × 10⁴ pfu of Vac-FL i.n. (A) Weight and (B) rectal temperature were measured daily to monitor overall progression of disease. Data are mean values ± SEM for percent weight loss or temperature, respectively. (C–E) Photon flux from regions-of-interest defined for the head (C), chest (D), and abdomen (E) on bioluminescent images over the course of infection. Data are mean values of background subtracted photon flux ± SEM. (F–I) Viral titers were quantified on days 3 and 5 post-infection (n = 3 per group) in the trachea (F), lung (G), brain (H), and spleen (I). Data are presented as mean values for viral titers ± SEM. 30 pfu/g tissue is the lower limit of detection for viral titers.

Fig. 3 — Protective effects of alveolar macrophages in sublethal vaccinia infection. Mice (n = 10) were injected intratracheally with clodronate or saline liposomes and then infected 2 days later with 4 × 10⁴ pfu of Vac-FL i.n. (A) Weight and (B) rectal temperature were measured daily to monitor overall progression of disease. Data are mean values ± SEM for percent weight loss or temperature, respectively. (C–E) Photon flux from regions-of-interest defined for the head (C), chest (D), and abdomen (E) on bioluminescent images over the course of infection. Data are mean values of background subtracted photon flux ± SEM. (F–I) Viral titers were quantified on days 3 and 5 post-infection (n = 3 per group) in the trachea (F), lung (G), brain (H), and spleen (I). Data are presented as mean values for viral titers ± SEM. 30 pfu/g tissue is the lower limit of detection for viral titers.