Table 3.
Comparative analysis of the ability to inhibit different ionotropic receptors by GABA-active ionophore ligands (legend as in Fig. 1)
Inhibition of ion channels
|
|||||||
---|---|---|---|---|---|---|---|
Receptors | P | BPH | BL | PTZ | PC | LA | NP |
GABA-A | yes | yes | yes | yes | Yes | yes | yes |
Invertebrate GABA | yes | yes | Yes | yes | |||
Acetylcholine N type | yes | ||||||
Glycine | yes | yes | |||||
5-HT3 serotonin | yes | no | yes | ||||
Glutamate | yes | no | |||||
References | (I) | (II) | (III) | (IV) | (I,V) |
References: I (Ffrench-Constant et al., 1993; Lynch et al., 1995; Zhang et al., 1995; Yoon et al., 1998; Etter et al., 1999; Shan et al., 2001, 2002; Le Corronc et al., 2002; Bloomquist, 2003; Das et al., 2003; Das and Dillon, 2003, 2005; Erkkila et al., 2004), II (Maksay et al., 1996; Yagle et al., 2003), III (Das et al., 2003), IV (Fujimoto et al., 1995; Hosie et al., 2006), V (Vale et al., 2003).