Table 1.
Selected genes differentially expressed in AEC II upon airway inflammation
| Gene (functional category) | Symbol | SPC-HA/TCR-HA/SPC-HA | Fold change | |
| Array1 | Array2 | Array1/Array2 | ||
| Genes associated with cell cycle | ||||
| cyclin D2 | Ccnd2 | 208/507 | 250/648 | -2,1/-2,1 |
| transforming growth factor, beta 3 | Tgfb3 | 93/311 | 87/188 | -3,0/-2,2 |
| Genes associated with cell adhesion | ||||
| procollagen, type IV, alpha 5 | Col4a5 | 89/208 | 72/224 | -1,9/-2,8 |
| procollagen, type XIV, alpha 1 | Col14a1 | 194/2003 | 142/1858 | -9,8/-13,1 |
| fibronectin 1 | Fn1 | 252/2564 | 407/2813 | -9,9/-8,6 |
| dermatopontin | Dpt | 250/5627 | 277/3997 | -11,8/-11,6 |
| claudin 18 | Cldn18 | 592/261 | 1845/445 | 2,3/3,9 |
| Genes associated with antigen presentation and processing | ||||
| major histocompatibility complex, class I, B | H2-Q7 | 1386/85 | 1666/109 | 17,6/20,3 |
| major histocompatibility complex, class II, DR alpha | H2-Ea | 5720/2661 | 5207/2187 | 2,2/2,4 |
| major histocompatibility complex, class II, DQ beta 2 | H2-Ab1 | 2217/1008 | 3971/1286 | 2,1/2,9 |
| major histocompatibility complex, class II, DQ alpha 1 | H2-Aa | 4028/2019 | 6314/1859 | 1,9/1,8 |
| major histocompatibility complex, class II, DR beta 1 | H2-Eb1 | 2072/1013 | 2882/1100 | 1,9/2,3 |
| major histocompatibility complex, class II, DM alpha | H2-DMa | 406/291 | 961/293 | 1,6/3,2 |
| proteasome (prosome, macropain) subunit, beta type, 7 | Psmb7 | 418/222 | 252/117 | 2,9/2,2 |
| proteasome (prosome, macropain) subunit, beta type, 8 | Psmb8 | 664/223 | 634/310 | 2,5/2,2 |
| proteasome (prosome, macropain) subunit, beta type, 9 | Psmb9 | 317/122 | 528/244 | 2,8/2,5 |
| beta-2-microglobulin | B2m | 8579/4177 | 8784/3119 | 2,1/2,9 |
| transporter 1 ATP-binding cassette, sub-family B (MDR/TAP) | Tap1 | 277/107 | 283/120 | 2,4/3,0 |
| Genes associated with transport | ||||
| potassium inwardly-rectifying channel, subfamily J, member 15 | Kcnj15 | 946/253 | 1160/231 | 4,0/4,9 |
| lipocalin 2 | Lcn2 | 11034/3130 | 13952/1966 | 3,6/7,4 |
| sodium channel, nonvoltage-gated, type I, alpha polypeptide | Scnn1a | 405/292 | 448/225 | 2,1/2,4 |
| Genes associated with immune response | ||||
| Chemokine (C-X-C motif) ligand 1 | CXCL1 | 313/96 | 235/64 | 2,5/3,1 |
| Chemokine (C-X-C motif) ligand 13 | CXCL13 | 128/556 | 100/634 | -4,5/-5,9 |
| Chemokine (C-C motif) ligand 12 | CXCL12 | 253/1827 | 211/1541 | -6,7/-7,4 |
| Chemokine (C-X-C motif) ligand 20 | CCL20 | 188/11 | 141/10 | 17,1/11,5 |
| chemokine (C-C motif) ligand 11 | CCL11 | 39/302 | 30/162 | -8,5/-4,1 |
| Genes associated with proteolysis and peptidolysis | ||||
| Matrix metalloproteinase 2 | MMP2 | 154/1788 | 116/1504 | -10,8/-10,3 |
| Matrix metalloproteinase 3 | MMP3 | 51/599 | 67/547 | -10,8/-10,9 |
| Matrix metalloproteinase 23 | MMP23 | 102/685 | 143/568 | -6,2/-3,8 |
| Tissue inhibitor of metalloproteinase 1 | TIMP1 | 54/842 | 70/569 | -11,1/-8,6 |
| Tissue inhibitor of metalloproteinase 2 | TIMP2 | 313/2265 | 388/2576 | -8,6/-8,5 |
| Tissue inhibitor of metalloproteinase 3 | TIMP3 | 623/2935 | 434/3363 | -3,0/-6,0 |
| Genes associated with cytoskelett | ||||
| elastin | Eln | 150/524 | 177/398 | -4,1/-2,5 |
| gelsolin | Gsn | 1438/16701 | 1620/15697 | -8,1/-9,7 |
| vimentin | Vim | 204/1974 | 308/2043 | -9,6/-6,5 |
| tubulin, alpha 1 | Tuba1 | 1285/6486 | 1145/6076 | -4,7/-5,3 |
| Genes associated with metabolism | ||||
| vanin 1 | Vnn1 | 1752/200 | 993/181 | 9,6/6,3 |
| 5,10-methylenetetrahydrofolate reductase | Mthfr | 141/300 | 114/276 | -2,0/-2,2 |
| paraoxonase 1 | Pon1 | 460/901 | 334/774 | -2,3/-2,4 |
| hexosaminidase B | Hexb | 94/303 | 93/228 | -2,5/-2,2 |
| Genes associated with signal transduction | ||||
| insulin-like growth factor binding protein 7 | Igfbp7 | 1356/4715 | 1849/5414 | -3,8/-2,52 |
| lipoprotein lipase | Lpl | 504/1542 | 228/1495 | -3,3/-5,5 |
| prosaposin | Psap | 236/761 | 319/963 | -3,9/-3,0 |
| fibroblast growth factor receptor 3 | Fgfr3 | 160/345 | 165/304 | -2,0/-3,2 |
| interleukin 11 receptor, alpha chain 1 | Il11ra1 | 88/428 | 146/350 | -2,7/-2,7 |
| Genes associated with signal transduction | ||||
| annexin A1 | Anxa11 | 1230/2328 | 866/1949 | -1,8/-2,4 |
| metallothionein 2 | Mt2 | 118/737 | 153/758 | -5,8/-7,1 |
| Genes associated with transcription | ||||
| thyrotroph embryonic factor | Tef | 350/189 | 429/203 | 2,2/2,3 |
| CREBBP/EP300 inhibitory protein 1 | Cri1 | 179/352 | 116/324 | -2,2/-3,1 |
| transcription factor 4 | Tcf4 | 92/462 | 142/519 | -5,0/-4,3 |
| necdin | Ndn | 216/1425 | 152/1895 | -5,5/-8,7 |
| Genes associated with development | ||||
| smoothened homolog (Drosophila) | Smo | 148/382 | 115/335 | -2,6/-2,7 |
| four and a half LIM domains 1 | Fhl1 | 704/3478 | 454/3561 | -4,7/-6,4 |
Differential gene expression was investigated by Affimetrix Gene Chip technology in AEC II from diseased SPC-HA/TCR-HA and healthy SPC-HA mice (n = 3). For each population two independent experiments were performed and data obtained from individual experiments are depicted. The table represents a compilation of regulated genes.