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. 2007 Aug 7;5(8):e214. doi: 10.1371/journal.pbio.0050214

Figure 5. Spatial Learning Promotes the Death of Newborn Neurons Generated a Few Days before Training.

Figure 5

(A) Latency to find the escape platform. Learning groups were injected with BrdU either 4 or 3 d before initiation of training as indicated by the syringes. D, day.

(B) Newly born cells measured by the number of BrdU-IR cells.

(C and D) Apoptotic cells measured by the number of fractin-IR cells (C) and both pyknotic and karyorrhexic dying cells (D).

(E) Number of BrdU-IR cells exhibiting characteristics of dying cells.

(F) Percentage of BrdU-IR cells expressing the immature neuronal marker Dcx.

(G) Extrapolated number of newborn neurons.

A single asterisk (*) indicates p ≤ 0.05, double asterisks (**) indicate p ≤ 0.01, and triple asterisks (***) indicate p ≤ 0.001 compared to Control groups. Error bars represent the s.e.m.