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Schematic illustration of different signaling pathway mediated by α3(IV)NC1. α3(IV)NC1 binds to αVβ3 and α3β1 integrins and inhibit phosphorylation of FAK. Inhibition of FAK activation leads to inhibition of FAK/phosphatidylinositol 3-kinase/eIF4E/4E-BP1. In addition, α3(IV)NC1 also inhibits NFκB-mediated signaling in hypoxic conditions leads to inhibition of COX-2/VEGF/bFGF expressions, resulting in inhibition of hypoxic tumor angiogenesis.
