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. 2007 Apr 23;110(4):1388–1396. doi: 10.1182/blood-2007-02-072389

Figure 2.

Figure 2

Change in modified Rodnan skin score (mRSS), modified Health Assessment Questionnaire (mHAQ) score, and organ function after high-dose immunosuppressive therapy (HDIT) and autologous hematopoietic cell transplantation. A determination was made as to whether a parameter value was statistically significantly increasing or decreasing over time using a generalized estimating equation (GEE) model. The bold black solid line represents the mean value over time for the parameter of interest. The bold black dotted line represents an estimate of the modeled linear relationship between the parameter value and time and summarizes the results of the GEE models. The gray solid lines are parameter values for individual patients. The mean mRSS and mHAQ values statistically significantly decreased with time after HDIT (both P < .001; panels A and B, respectively). The mean values for diffusion capacity of the lung for carbon monoxide (DLCO) adjusted for hemoglobin levels did not statistically significantly change (P = .50, panel C), and forced vital capacity statistically significantly increased with time (P = .01, panel D). The mean values for serum creatinine and ejection fraction statistically significantly increased and decreased with time (P = .01 and P = .04; panels E and F, respectively).