Table 4.

In vitro effects of various drugs and bioactive compounds of Mediterranean diet on PAF-CPT activity of HMC. Preliminary results represent the average of two independent experiments using different enzyme preparations performing duplicate samples. Results are expressed as percentage of inhibition of PAF-CPT activity versus control (absence of these factors).

Bioactive compound	Drug name/food origin	Action	Concentration in assay	Inhibition of PAF-CPT (%)
Rupatadine	Rupafin	(i) Antiallergic [31]	20 ng/μL	60
		(ii) PAF-antagonist [31]
Simvastatin	Zocor	(i) Antiatherogenic [32]	40 ng/μL	92
		(ii) Anticancer [33]
INFa	IntronA	Anticancer [34]	250 IU/μL	51
Tinzaparin	Innohep	(i) Antithrombotic [35]	0.25 IU/μL	30
		(ii) Anticancer [36]
Salicylic acid	Aspirin	(i) Anti-inflammatory [37]	250 ng/μL	38
		(ii) Anticancer [38]
Resveratrol	—	(i) Antioxidant [39]	100 μM	39
		(ii) Anti-PAF [39]
		(iii) Anticancer [39]
Polar lipids	Olive oil	(i) Antiatherogenic [40]	5.2 ng/μL	33
		(ii) Anti-PAF [40]
		(iii) Anticancer [41]
Polar lipids	Olive pomace	(i) Antiatherogenic [26, 40]	1.8 ng/μL	48
		(ii) Anti-PAF [26, 40]
Polar lipids	Sea bass	Anti-PAF [27]	59 ng/μL	45
Polar lipids	Sea bream	Anti-PAF [27]	123 ng/μL	17