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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Cancer Cell. 2007 Mar;11(3):217–227. doi: 10.1016/j.ccr.2006.12.017

Figure 5.

Figure 5

The G719S mutation alters the binding mode of staurosporine analog AFN941. (A) The wild-type EGFR in complex with AFN941. Hydrogen bonds (dashed lines) are formed with the backbone amides of Met 793 in the hinge region and Gly 719 in the P-loop. (B) Structure of the G719S mutant in complex with AFN941. The serine substitution displaces and rotates the inhibitor, disrupting the hydrogen bond with the P-loop and promoting additional interactions with the backbone carbonyls of Gln 791 and Arg 841.