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. Author manuscript; available in PMC: 2007 Aug 6.
Published in final edited form as: J Vasc Surg. 2007 Jun;45(6S):33–38. doi: 10.1016/j.jvs.2007.02.069

Figure 1.

Figure 1

Leading animal models of arterial injury. A. The balloon angioplasty model results in a disruptive injury to the intima and media leading to neointimal hyperplastic lesion formation with a significant SMC contribution from the bone marrow. B. The carotid ligation (flow cessation) model results in little or no disruptive injury to the media. The seminal event appears to be a directional SMC migration from the media to the neointima with little or no contribution from the bone marrow. C. Like the carotid ligation model, the critical event appears to be SMC migration with minimal or no medial disruption and bone marrow contribution.