Skip to main content
. Author manuscript; available in PMC: 2007 Aug 6.
Published in final edited form as: J Vasc Surg. 2007 Jun;45(6S):33–38. doi: 10.1016/j.jvs.2007.02.069

Table 1.

Scientific investigations on the effectiveness of the β3 integrin antagonists in the inhibition of intimal lesion formation in various animal models of arterial injury.

Species Antagonist against β3 integrin Artery Type of injury IH lesion reduction? Reference
Rat ReoPro αvβ3, αIIbβ3 Carotid Angioplasty Yes 25,44
Rat Gpen αvβ3 Carotid Angioplasty Yes 45
Hamster Gpen αvβ3 Carotid Angioplasty Yes 46
Hamster FK633 αIIbβ3 Carotid Angioplasty Yes 47
Rabbit Gpen αvβ3 Carotid Angioplasty Yes 24
Rabbit Vitaxin αvβ3 Carotid Angioplasty Yes 48
Rabbit AZ-1 αIIbβ3 Femoral Angioplasty No 33
Pig XJ 735 αvβ3 Coronary Stenting Yes 28
Monkey ReoPro αvβ3, αIIbβ3 Iliac Angioplasty No 34
Monkey ReoPro αvβ3, αIIbβ3 Subclavian Stenting No 34

IH (intimal hyperplastic).