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. Author manuscript; available in PMC: 2008 Jun 8.
Published in final edited form as: Mol Cell. 2007 May 31;26(5):745–752. doi: 10.1016/j.molcel.2007.05.010

Figure 4. Expression of miR-34a leads to widespread alterations in gene expression.

Figure 4

(A) Northern blot showing miR-34a expression in retrovirally-infected cell populations.

(B) Northern blot validation of selected expression changes observed by microarray analysis.

(C) Sites complementary to the miR-34a seed are enriched in the 3′ UTRs of downregulated transcripts. The graph shows the frequency of a site complementary to the miR-34a seed in the 3′ UTRs of the top 100 downregulated genes (2.364-fold or greater downregulation), the unchanged genes, and the genes upregulated by 2.364-fold or greater.