(A) Northern blot showing miR-34a expression in retrovirally-infected cell populations.
(B) Northern blot validation of selected expression changes observed by microarray analysis.
(C) Sites complementary to the miR-34a seed are enriched in the 3′ UTRs of downregulated transcripts. The graph shows the frequency of a site complementary to the miR-34a seed in the 3′ UTRs of the top 100 downregulated genes (2.364-fold or greater downregulation), the unchanged genes, and the genes upregulated by 2.364-fold or greater.