Figure 2.

Time-dependent changes in the overall miRNA expression levels. Mice pre-treated intraperitoneally for 1 hr with either saline or dexamethasone, were challenged with either aerosilised saline or LPS. At the indicated time, the mean ± SEM (n = 5) of the change in lung tissue levels for 104 mature miRNAs was determined relative to time-matched saline controls (equivalent to 1). Statistical significance was determined by ANOVA followed by Tukey's post-test where ** = p < 0.01 and *** = p < 0.001 versus saline and ### = p < 0.001 for dexamethasone-LPS versus LPS-only treated animals.