Table 2.
Genes Differentially Expressed in POAG TM Compared with Normal TM
| Category | Gene Name | Common Name | Geometric Mean of Intensities in Normal | Geometric Mean of Intensities In POAG | Change(X-fold) | Parametric P |
|---|---|---|---|---|---|---|
| Apoptosis | CCL2 | Monocyte chemotactic protein(MCP-1) | 58.1 | 226.7 | 3.9 | 0.0037 |
| INHBA | Inhibin, beta A (activin A) | 46.1 | 115.5 | 2.5 | 0.0131 | |
| SULF1 | Extracellular sulfatase 1 | 12.4 | 21.4 | 1.7 | 0.0408 | |
| CLU | Complement cytolysis inhibitor(clusterin) | 2075 | 1186.9 | −1.7 | 0.0489 | |
| Cell adhesion | CCL5 | T-cell–specific protein (RANTES) | 26.3 | 67.2 | 2.5 | 0.0331 |
| ICAM1 | Intercellular adhesion molecule1(ICAM1) | 46.6 | 98 | 2.1 | 0.0355 | |
| PECAM1 | Platelet endothelial cell adhesion molecule (PECAM1) | 55 | 110.6 | 2.0 | 0.0427 | |
| SELP | P-selectin (PADGEM) | 20.8 | 40.2 | 1.9 | 0.0235 | |
| ECM GAG composition | LUM | Keratan sulfate proteoglycan(lumican) | 7.8 | 17.9 | 2.3 | 0.0179 |
| FUT8 | α (1,6) fucosyltransferase | 29.6 | 44.9 | 1.5 | 0.0477 | |
| IDS | Iduronate-2-sulfatase | 65.9 | 99.5 | 1.5 | 0.0203 | |
| CHST12 | Chondroitin 4-O-sulfotransferase 2 | 189.4 | 124.2 | −1.5 | 0.0217 | |
| Cell proliferation | OGN | Osteoglycin (mimecan) | 315.6 | 592.5 | 1.9 | 0.0105 |
| PDGFRB | PDGF receptor | 319.6 | 191.7 | −1.7 | 0.0385 | |
| BMP4* | Bone morphogenetic protein 2B(BMP 2b) | 616.2 | 371 | −1.7 | 0.0150 | |
| (BMP2B) | Bone morphogenetic protein 4(BMP 4) | 642.5 | 397.4 | −1.6 | 0.0216 | |
| MST1 | Macrophage-stimulating factor 1(HGF-like) | 188.6 | 125.9 | −1.5 | 0.0351 | |
| CD69 | Early T-cell-activation antigen | 8.9 | 13.1 | 1.5 | 0.0159 | |
| Cell communication | IL6R | Interleukin 6 receptor | 12.7 | 18.7 | 1.5 | 0.0189 |
Genes are considered differentially expressed when there is a difference of 1.4-fold or more between the geometric mean signal of the POAG group (n = 3) and the normal group (n = 4).
*
BMP4 and BMP2B are the same gene, submitted under different accession numbers.