Table 1.
Glutamate Receptors.
| Isoforms | Glutamate Response | ||
|
| |||
| Ionotropic | NMDA | NR1, NR2A-D and NR3A-B | Increase Ca2+/Na+ intracellular influx |
| AMPA | GluR1, GluR2, GluR3, and GluR4 | Increase Na+/(Ca2+) intracellular influx | |
| Kainate | GluR5, GluR6, GluR7, KA1, and KA2 | Increase Na+/(Ca2+) intracellular influx | |
|
| |||
| Metabotropic | Type I | mGluR1, mGluR5 | Increase intracellular inositol phosphate and diacylglycerol |
| Type II | mGluR2, mGluR3 | Decrease intracellular cyclic adenosine monophosphate | |
| Type III | mGluR4, mGluR6, mGluR7, and mGluR8 | Modulate intracellular cyclic adenosine monophosphate | |