Table 3.
Joint effects of toenail arsenic measurements and nucleotide excision repair polymorphisms on risk of NMSC.
| Gene, polymorphism | Toenail arsenic (μg/g) | Controls [n (%)] | BCC [n (%)] | OR (95% CI)a | SCC [n (%)] | OR (95% CI)a |
|---|---|---|---|---|---|---|
| XPA, A23G | n = 773 | n = 868 | n = 662 | |||
| GG | ≤ 0.286 | 334 (43.2) | 399 (46.0) | Referent | 309 (46.7) | Referent |
| > 0.286 | 13 (1.7) | 29 (3.3) | 1.8 (0.9–3.7) | 13 (2.0) | 1.1 (0.5–2.6) | |
| AG, AA | ≤ 0.286 | 401 (51.9) | 413 (47.6) | 0.8 (0.7–1.0) | 323 (48.8) | 0.8 (0.7–1.1) |
| > 0.286 | 25 (3.2) | 27 (3.1) | 0.9 (0.5–1.6) | 17 (2.6) | 0.8 (0.4–1.6) | |
| p-Value for interactionb | 0.24 | 0.79 | ||||
| XPD, Asp312Asn | n = 728 | n = 782 | n = 631 | |||
| Asp/Asp | ≤ 0.286 | 282 (38.7) | 320 (40.9) | Referent | 276 (43.7) | Referent |
| > 0.286 | 19 (2.6) | 27 (3.4) | 1.3 (0.7–2.4) | 10 (1.6) | 0.6 (0.3–1.3) | |
| Asp/Asn, Asn/Asn | ≤ 0.286 | 409 (56.2) | 411 (52.6) | 0.8 (0.7–1.0) | 326 (51.7) | 0.8 (0.6–1.0) |
| > 0.286 | 18 (2.5) | 24 (3.1) | 1.2 (0.6–2.2) | 19 (3.0) | 1.2 (0.6–2.4) | |
| p-Value for interactionb | 0.82 | 0.08 | ||||
| XPD, Lys751Gln | n = 753 | n = 854 | n = 644 | |||
| Lys/Lys | ≤ 0.286 | 303 (40.2) | 368 (43.1) | Referent | 280 (43.5) | Referent |
| > 0.286 | 19 (2.5) | 27 (3.2) | 1.2 (0.6–2.2) | 9 (1.4) | 0.6 (0.2–1.3) | |
| Lys/Gln, Gln/Gln | ≤ 0.286 | 416 (55.3) | 431 (50.5) | 0.8 (0.7–1.0) | 336 (52.2) | 0.8 (0.6–1.0) |
| > 0.286 | 15 (2.0) | 28 (3.3) | 1.6 (0.8–3.2) | 19 (2.9) | 1.6 (0.8–3.4) | |
| p-Value for interactionb | 0.31 | 0.03 |
a
Odds ratios controlled for age, sex, severe sunburns, and pigmentation.
b
From test of interaction with 1 df.