Table 4.
Combination of XPD polymorphisms Asp312Asn and Lys751Gln and risk of NMSC in BCC (n = 771), and SCC (n = 617), and controls (n = 710).
| XPD 312 | XPD 751 | Controls[n (%)] | BCC [n (%)] | OR (95% CI)a | SCC [n (%)] | OR (95% CI)a |
|---|---|---|---|---|---|---|
| Asp/Asp | Lys/Lys | 236 (33.2) | 271 (35.2) | Referent | 221 (35.8) | Referent |
| Lys/Gln, Gln/Gln | 60 (8.5) | 72 (9.3) | 1.0 (0.7–1.6) | 60 (9.7) | 1.1 (0.7–1.6) | |
| Asp/Asn, Asn/Asn | Lys/Lys | 55 (7.8) | 79 (10.3) | 1.1 (0.7–1.7) | 53 (8.6) | 1.0 (0.6–1.6) |
| Lys/Gln, Gln/Gln | 359 (50.6) | 349 (45.3) | 0.8 (0.6–1.0) | 283 (45.9) | 0.8 (0.6–1.0) |
a
Odds ratios controlled for age, sex, severe sunburns, and pigmentation.