Table 5.
XPD polymorphisms Asp312Asn and Lys751Gln, toenail arsenic, and risk of NMSC in BCC (n = 771), SCC (n = 617), and controls (n = 710).
| Toenail arsenic (μg/g) | XPD 312 | XPD 751 | Controls [n (%)] | BCC [n (%)] | OR (95% CI)a | SCC [n (%)] | OR (95% CI)a |
|---|---|---|---|---|---|---|---|
| ≤ 0.286 | Asp/Asp | Lys/Lys | 219 (30.9) | 249 (32.3) | Referent | 214 (34.7) | Referent |
| Lys/Gln, Gln/Gln | 58 (8.2) | 67 (8.7) | 1.0 (0.7–1.5) | 57 (9.2) | 1.0 (0.6–1.5) | ||
| Asp/Asn, Asn/Asn | Lys/Lys | 53 (7.5) | 77 (10.0) | 1.1 (0.7–1.7) | 52 (8.4) | 1.0 (0.6–1.5) | |
| Lys/Gln, Gln/Gln | 347 (48.9) | 328 (42.5) | 0.8 (0.6–1.0) | 267 (43.3) | 0.7 (0.6–0.9) | ||
| > 0.286 | Asp/Asp | Lys/Lys | 17 (2.4) | 22 (2.9) | 1.1 (0.6–2.2) | 7 (1.1) | 0.5 (0.2–1.2) |
| Lys/Gln, Gln/Gln | 2 (0.3) | 5 (0.7) | 2.6 (0.5–14.7) | 3 (0.5) | 1.4 (0.2–8.9) | ||
| Asp/Asn, Asn/Asn | Lys/Lys | 2 (0.3) | 2 (0.) | 1.1 (0.1–7.7) | 1 (0.2) | 0.4 (0.03–6.2) | |
| Lys/Gln, Gln/Gln | 12 (1.7) | 21 (2.7) | 1.6 (0.7–3.4) | 16 (2.6) | 1.7 (0.7–3.8) | ||
| p-Value for interactionb | 0.61 | 0.07 |
a
Odds ratios controlled for age, sex, severe sunburns, and pigmentation.
b
From test for interaction (3 df) between arsenic and the combined XPD polymorphisms at codons 312 and 751.