Fig 5.

Src signalling pathways.

The Src protein has three functioning molecular domains. SH2 (SRC homology 2) and SH3 are involved in protein-protein interactions. The third, SH1 is a kinase catalytic domain. Src can transfer from inactive to active state through control of its phosphorylation state, or via protein-protein interactions. FAK (focal adhesion kinase) and PDGF (platelet derived growth factor) are capable of rendering Src active by binding to its SH2 domain⁵⁰.

GPCR: G-protein coupled receptors EGF: epidermal growth factor