Figure 4.

(A) The sequence of the SL1 region of human G-CSF cDNA aligned with the homologous region from the murine G-CSF cDNA. The alignment of GenBank entries HSGCSFR (21) and MUSGCSF (22) was made using the GCG program gap. (B) Various sequences inserted into the 3′UTR of the fGH gene. SL1, from the 3′UTR of human G-CSF, includes two putative stem–loops that are conserved in the mouse and human mRNAs. The 124-base sequence between the stems and 8 bases 3′ of stem–loop B are not shown. The other sequences were derived from SL1 as shown.