Figure 5.

The effects of SL1 and its derivatives on the stability of the fGH mRNA. The sequences inserted into fGH are described in Fig. 4. RNA was isolated at various times after serum stimulation of NIH 3T3 cells stably transfected with variants of the fGH gene containing the indicated sequences inserted in the 3′UTR. The stability of the fGHSL2 mRNA was unchanged by treatment of the cells with the calcium ionophore A23187. The dashed line in the graph at right shows the fGHSL1 data replotted for comparison.