Table 1.

Immunomodulatory properties of several Leishmania proteins.

Protein	Properties	References
Leishmania Sir2	Secreted, B-cell activator, induces lytic, and neutralizing antibodies	[64, 65]
LicTXNPx	Secreted, elicits strong humoral response and has no influence on	[63]
	cytokine production
LimTXNPx	Nonsecreted, decreases IL-4 secretion both in vitro and in vivo	Figure 3
LiTXN1	Secreted, poorly immunogenic, induces IL-10 secretion both in vitro	(Manuscript in
	and in vivo	preparation)
LmS3arp	Nonsecreted, B-cell polyclonal activator, inhibits T-cell proliferation	[67]
	and downregulate IL-2, 12 and IFN-γ in splenocytes