Table 2.

Effect of treatment with PPAR agonists on body weight (BW), body composition (FM and LM), and liver weight (LW). Shown in the table are body weight (g) and fat and lean mass (g) values of each group. FM and LM were determined using qMR at the final day of the study (day 28). LW was obtained from terminal collection at the end of the experiment. N = 8 mice/group. Data are expressed as mean +/− SEM. Doses are in mg/kg. Data were analyzed by two-way ANOVA with repeated measures followed by post hoc t-test. Data achieved significance when P < .05(*).

	Treatment	BW day 0 (grams)	BW day 28 (grams)	Fat mass day 28 (grams)	Lean mass day 28 (grams)	Liver weight (grams)
Experiment 1	Lean vehicle	36.6 ± 0.8	37.0 ± 1.0	8.4 ± 1.1	23.2 ± 0.4	1.8 ± 0.1
	DIO vehicle	50.4 ± 1.3	52.1 ± 1.8	20.8 ± 1.3	29.3 ± 0.7	2.0 ± 0.2
	GW9578 (1)	52.1 ± 1.1	51.3 ± 1.6	18.4 ± 0.9	30.9 ± 0.8	2.6 ± 0.1*
	GW0742 (30)	51.6 ± 1.1	50.2 ± 1.2	18.4 ± 0.7*	29.7 ± 0.7	3.2 ± 0.1*
	GW9578 + GW4148 (after week 2)	49.0 ± 0.6	41.3 ± 1.2*	10.2 ± 0.9*	29.1 ± 0.5	4.3 ± 0.2*
	GW4148 + GW9578 (after week 2)	49.5 ± 1.0	42.7 ± 0.8*	11.0 ± 0.8*	29.5 ± 0.9	4.3 ± 0.1*
	GW9578 and GW4148 4 weeks	50.5 ± 0.9	39.3 ± 0.9*	9.1 ± 0.4*	28.4 ± 0.7	4.9 ± 0.1*
Experiment 2	DIO vehicle	50.8 ± 0.4	49.2 ± 0.5	20.7 ± 0.8	25.4 ± 1.0	1.9 ± 0.1
	RIM (10)	50.6 ± 0.8	44.1 ± 1.3*	15.0 ± 0.9	25.2 ± 0.8	2.0 ± 0.1
	RIM (30)	51.0 ± 0.7	41.8 ± 0.5*	11.6 ± 0.3	26.5 ± 0.5	2.0 ± 0.1
	GW7845 (3)	50.9 ± 1.2	54.6 ± 1.7*	23.5 ± 1.3	28.7 ± 0.6	2.0 ± 0.1
Experiment 3	DIO vehicle	40.8 ± 1.3	44.9 ± 1.6	17.6 ± 1.6	23.5 ± 0.5	1.9 ± 0.1
	GW4148 (3)	40.8 ± 1.2	42.0 ± 0.9	13.5 ± 0.9*	23.7 ± 0.3	2.9 ± 0.1*
	GW4148 (10)	40.7 ± 1.5	36.6 ± 0.9*	10.3 ± 0.6*	22.3 ± 0.5	3.4 ± 0.1*
Experiment 4	Lean vehicle	33.7 ± 0.7	34.4 ± 0.8	8.4 ± 0.8	22.0 ± 0.6	1.7 ± 0.1
	DIO vehicle	40.6 ± 1.9	43.1 ± 1.6	16.5 ± 1.1	23.4 ± 0.6	1.9 ± 0.1
	GW9135 (3)	41.1 ± 1.8	42.5 ± 1.9	14.9 ± 1.5	24.1 ± 0.3	3.0 ± 0.2*
	GW9135 (10)	41.2 ± 1.5	40.3 ± 1.2	12.3 ± 0.8*	23.0 ± 0.4	3.3 ± 0.1*