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Guanylate cyclase activity as a function of Npr1 gene copy number. Ordinate gives the rate of ANP-stimulated cGMP synthesis in lung (A) and kidney (B) membrane preparations from both male and female animals with one, two, three, and four copies of the Npr1 gene as a percent of the rate of normal two-copy animals. Solid squares represent the means of five animals for each genotype. Error bars represent the SEMs.
