Figure 3.

(A) Tail-cuff blood pressures of male F₁ animals having one, two, or three copies of the Npr1 gene. Twelve animals for each genotype were successively fed diets containing the indicated content of NaCl. (B) Tail-cuff blood pressures of male F₃ mice having four copies of Npr1 (n = 12) and fed the same diets. (Results of the four-copy mice are graphed separately because the F₃ mice are genetically distinct from the F₁ animals.) Vertical bars represent mean values of each group of animals. Error bars represent SEMs. ∗, P < 0.001 compared with two-copy controls; ^†, P < 0.01 compared with two-copy controls; ^‡, P < 0.05 compared with 0.05% salt.