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. 1972 Oct 7;107(7):617–622.

Glucagon-initiated human growth hormone release: a comparative study

John P Cain, Gordon H Williams, Robert G Dluhy
PMCID: PMC1940964  PMID: 4665093

Abstract

Human growth hormone (HGH) responses in 20 healthy adults to subcutaneous glucagon, arginine infusion and tolbutamide and insulin hypoglycemia were compared. HGH rose in all four tests. HGH response to glucagon was also studied in 49 patients with suspected pituitary insufficiency, of whom 25 also later received an arginine infusion; an abnormal response to glucagon was the most frequent functional abnormality and often HGH was the only anterior pituitary hormone of which a deficiency was detectable. In seven subjects (two healthy controls and five patients with suspected hypopituitarism) there was a subnormal HGH response to arginine but a normal response to glucagon. It is concluded that glucagon is a simple and effective stimulus to HGH release, equal or superior to arginine, tolbutamide and insulin, and is an important test of anterior pituitary function.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cain J. P., Williams G. H., Dluhy R. G. Glucagon stimulation of human growth hormone. J Clin Endocrinol Metab. 1970 Aug;31(2):222–224. doi: 10.1210/jcem-31-2-222. [DOI] [PubMed] [Google Scholar]
  2. DOLE V. P., MEINERTZ H. Microdetermination of long-chain fatty acids in plasma and tissues. J Biol Chem. 1960 Sep;235:2595–2599. [PubMed] [Google Scholar]
  3. Danforth E., Jr, Rosenfeld P. S. Effect of intravenous glucagon on circulating levels of growth hormone and 17-hydroxycorticosteroids. J Clin Endocrinol Metab. 1970 Jan;30(1):117–119. doi: 10.1210/jcem-30-1-117. [DOI] [PubMed] [Google Scholar]
  4. Eddy R. L., Jones A. L., Hirsch R. M. Effect of exogenous glucagon on pituitary polypeptide hormone release. Metabolism. 1970 Oct;19(10):904–912. doi: 10.1016/0026-0495(70)90088-0. [DOI] [PubMed] [Google Scholar]
  5. Glick S. M. Hypoglycemic threshold for human growth hormone release. J Clin Endocrinol Metab. 1970 May;30(5):619–623. doi: 10.1210/jcem-30-5-619. [DOI] [PubMed] [Google Scholar]
  6. Merimee T. J., Bergess J. A., Rabinowitz D. Sex-determined variation in serum insulin and growth hormone response to amino acid stimulation. J Clin Endocrinol Metab. 1966 Jul;26(7):791–793. doi: 10.1210/jcem-26-7-791. [DOI] [PubMed] [Google Scholar]
  7. Merimee T. J., Rabinowtitz D., Fineberg S. E. Arginine-initiated release of human growth hormone. Factors modifying the response in normal man. N Engl J Med. 1969 Jun 26;280(26):1434–1438. doi: 10.1056/NEJM196906262802603. [DOI] [PubMed] [Google Scholar]
  8. Milner R. D., Wright A. D. Plasma glucose, non-esterified fatty acid, insulin and growth hormone response to glucagon in the newborn. Clin Sci. 1967 Apr;32(2):249–255. [PubMed] [Google Scholar]
  9. Mitchell M. L., Byrne M. J., Sanchez Y., Sawin C. T. Detecon of growth-hormone deficiency. N Engl J Med. 1970 Mar 5;282(10):539–541. doi: 10.1056/NEJM197003052821005. [DOI] [PubMed] [Google Scholar]
  10. Nugent C. A., Mayes D. M. Plasma corticosteroids determined by use of corticosteroid-binding globulin and dextran-coated charcoal. J Clin Endocrinol Metab. 1966 Oct;26(10):1116–1122. doi: 10.1210/jcem-26-10-1116. [DOI] [PubMed] [Google Scholar]
  11. ROTH J., GLICK S. M., YALOW R. S., BERSON S. A. Secretion of human growth hormone: physiologic and experimental modification. Metabolism. 1963 Jul;12:577–579. [PubMed] [Google Scholar]
  12. ROTH J., GLICK S. M., YALOW R. S., BERSONSA Hypoglycemia: a potent stimulus to secretion of growth hormone. Science. 1963 May 31;140(3570):987–988. doi: 10.1126/science.140.3570.987. [DOI] [PubMed] [Google Scholar]
  13. Rabkin M. T., Frantz A. G. Hypopituitarism: a study of growth hormone and other endocrine functions. Ann Intern Med. 1966 Jun;64(6):1197–1207. doi: 10.7326/0003-4819-64-6-1197. [DOI] [PubMed] [Google Scholar]
  14. Service F. J., Molnar G. D., Rosevear J. W., Ackerman E., Taylor W. F., Cremer G. M., Moxness K. E. Continuous blood glucose analysis in ambulatory fed subjects. II. Effects of anticoagulation with heparin. Mayo Clin Proc. 1969 Jul;44(7):466–477. [PubMed] [Google Scholar]
  15. Streeto J. M. Late post-glucose rise in plasma growth hormone as a test of pituitary function. J Clin Endocrinol Metab. 1970 Jul;31(1):84–85. doi: 10.1210/jcem-31-1-84. [DOI] [PubMed] [Google Scholar]
  16. Weber B., Helge H., Quabbe H. J. Glucagon-induced growth hormone release in children. Acta Endocrinol (Copenh) 1970 Oct;65(2):323–341. doi: 10.1530/acta.0.0650323. [DOI] [PubMed] [Google Scholar]

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