Fig. 2.

The Ptcra enhancer contains unmethylated windows in numerous tissues. (A) An alignment of the mouse (m) and human (h) Ptcra enhancer core sequences. Previously identified transcription factor binding sites are boxes, and CpG locations are indicated. (B) Methylation profiles for the Ptcra enhancer and promoter in various cells and tissues. Results from a minimum of two experiments are shown for blastocysts, CCE ES cells, thymocytes, BMDM, and sperm cells. Results obtained with the HSC, MPP, CLP, and CMP populations are also described in Attema et al. (40). The same data with the ratio values are shown in SI Fig. 17.