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IGF2 E domain mutations in Poeciliopsis. (A) Sequence alignment of P. monacha, P. prolifica, and P. lucida illustrating the deletion of the 3′ 15 bases of exon 2 in P. prolifica and P. lucida. The deletion results in the recruitment of sequences that would have been intronic and utilization of a cryptic intronic splice donor site. (B) Conserved site of proteolysis to remove the E domain from the IGF2 prohormone. The nonconservative change (S→A) in P. infans is highlighted in yellow.
