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Biochemical analysis of TDP-43. Immunoblot analysis probed with anti-TDP-43 antibody demonstrated a distinct pathological profile of TDP-43 with variable presence of pathological ∼25-kd bands (*), 45-kd bands (**), and high molecular smear (***) in all sporadic and familial FTLD-U brains (FTLD-U subtypes 1 to 3), including those with progranulin (GRN) and VCP mutations and those linked to chromosome 9p (Chrom. 9). Pathological TDP-43 bands were not detected in control brains (CO).
