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. 2007 Jul;171(1):315–325. doi: 10.2353/ajpath.2007.061078

Figure 5.

Figure 5

Characterization of in vitro regulation of the vessel tone in IL-6−/− aortic rings. Aortic ring functional responses were determined as described in Materials and Methods. A: PE constriction dose response in aortic rings in the presence or absence of 300 μmol/L l-NAME (n = 8 to 9). B: ACh-relaxation dose response in PE-preconstricted aortic rings in the presence or absence of 300 μmol/L l-NAME (n = 8 to 9). C: Constriction dose response to PE in aortic rings in the presence or absence of 10 μmol/L indomethacin (n = 8 to 9). D: Relaxation dose response to ACh in PE-preconstricted aortic rings in the presence or absence of 10 μmol/L indomethacin (n = 8 to 9). Data are expressed as mean ± SEM. ★★P < 0.01 compared with WT group; ★★★P < 0.001 compared with WT group using two-way analysis of variance with Bonferroni’s posttest to isolate differences between groups.