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Schematic representation of the putative models for the complex of K48-linked Ub2 and the tandem-UIM fragment of S5a. Panels (a) and (b) show two possible ways the S5a UIMs can contact individual Ub units in Ub2. The linker connecting UIMs in S5a is flexible in solution 8. Preliminary structural models of the complex obtained by superimposition of the structures of the corresponding UIM/monoUb complexes can be found in Supplementary Material.
