Table 7.

Significance levels when testing the positivity or negativity of the region-wise mean using permutation tests for different sequence types

	P1	P2	Maximum T	Minimum T	T threshold
SPGR BC+N3	0.394	0.008	4.42	−6.45	±7.35
SPGR BC−N3	0.471	0.015	5.55	−8.33	±7.3
MP-RAGE BC+N3	0.362	0.046	9.90	−7.30	±7.03
MP-RAGE BC−N3	0.976	0.301	4.93	−6.49	±6.90
IR-SPGR BC+N3	0.173	0.038	7.49	−9.99	±10.58
IR-SPGR BC−N3	0.992	0.303	5.54	−8.96	±10.8
SYN BC+N3	0.827	0.039	5.40	−6.02	±7.29
SYN BC−N3	0.772	0.021	5.28	−6.22	±7.28

P1 (P2) is the significance level of the alternative hypothesis that the region-wise mean is positive (negative), while Max (Min) T is the maximal (minimal) voxelwise T statistic inside the ROI defined by a mask of the average brain template (ICBM-53) in ICBM space. The T threshold is the corrected cut-off T value obtained using 10,000 permutations on the maximum/minimum statistic (at the P = 0.05 level). Voxels with T values more extreme than the corrected cut-off T threshold are considered active (since we should detect no change within a 2-week period, these voxels are considered false positives under the null hypothesis).