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. 2007 Jul;9(7):589–600. doi: 10.1593/neo.07358

Figure 1.

Figure 1

CITED1 immunoperoxidase staining (brown) of rat fetal kidney (A) and NEU-induced nephroblastoma (B and C). (A) CITED1 expression in rat fetal kidney (FK) 16.5 dpc is restricted to the condensed metanephric mesenchyme (CM) immediately adjacent to and surrounding UB tubular structures (original magnification, x400). Note the absence of CITED1 expression in the early renal vesicle (RV) epithelia of mesenchymal origin. (B) CITED1 expression in rat nephroblastoma (WT) is intense in blastemal elements (brown) and absent in primitive epithelia (white arrows, tubules; black arrowhead, glomerulus) and stroma (St) (original magnification, x400). (C) The region of blastemal-to-epithelial transition shows downregulation of CITED1 expression in a gradient from positive peripheral blastema to negative central epithelia (arrows) (original magnification, x200).