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. 2007 Jul;9(7):589–600. doi: 10.1593/neo.07358

Figure 7.

Figure 7

In situ hybridization detects CITED1 mRNA in rat (A) and human (B–D) nephroblastoma (WT). (A) Rat WT shows that CITED1 mRNA is restricted to blastemal compartments (Bl; dark regions). CITED1 mRNA is also detected in peripheral blastema (arrows) immediately surrounding more differentiated tumor epithelia (Ep). Epithelial and stromal (St) compartments do not express CITED1 mRNA. (B) Human WT shows CITED1 mRNA restriction to blastemal compartments (Bl; dark regions) and absence in stroma (St). (C) Epithelial-predominant human WT showing no detection of CITED1 mRNA in either epithelia (Ep) or stroma (St). (D) Sense control showing no detection of radiolabeled probe.