Figure 3.

Mean arterial blood pressure. The mean arterial blood pressure was measured for 4 h in the rats. A. Either irrelevant monoclonal IgG (Control IgG, filled squares), rabbit polyclonal anti-PcrV IgG (Rab anti-PcrV, open diamonds), or murine monoclonal anti-PcrV IgG (Mab166, open circles) (4 mg/kg, respectively) was co-instilled with P. aeruginosa PA103 (5 × 10⁷ CUF) in the airspaces of the rats. B. Either PBS without IgG (w/o IgG, filled squares), rabbit polyclonal anti-PcrV IgG (Rab anti-PcrV, open diamonds), murine monoclonal anti-PcrV IgG (Mab166, open circles), or Fab fragments Mab166 (Mab166 Fab, open triangles) (4 mg/kg, respectively) was intratracheally instilled one hour after the airspace instillation of P. aeruginosa PA103 (5 × 10⁷ CUF). Data are shown as means ± standard errors. The numbers of animals are listed in Table 1. *P < 0.05 in the Mab166 group to the control group (w/o IgG) at the 4 h time point by unpaired t-test.