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. 2007 Aug 10;3(8):e130. doi: 10.1371/journal.pgen.0030130

Figure 2. Developmental Phenotypes of Trip13 Mutant Mice.

Figure 2

(A) Shown are 21-d-old littermates. Note the shortened tail in the mutant, but overall similar body size.

(B) Shown are 23-d-old littermates. The mutant is smaller in this case, but the tail is not as truncated as the mouse in (A).

(C) Wild-type (WT) and homozygous Trip13 mutant (MUT) testes.

(D) and (E) are cross sections through 17.5-d-old heterozygous (“WT”) and homozygous mutant Trip13 testes, respectively. Whereas the tubules in WT show coordinated spermatogenesis with pachytene spermatocytes present in all tubules (proximal to the lumen), developmental progression in the mutant is not synchronized between tubules. Some tubules have no pachytene spermatocyes (asterisks), while in others, development is somewhat disorganized (#).