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Theoretical model for transient AAV dsDNA in rAAV transduction life cycle. (A) Transient dsDNA status during AAV2 transduction. (B) Transient dsDNA during AAV8 transduction. The difference between AAV2 and AAV8 in uncoating is noted in the figure as “slow” and “fast.” The traditional rate-limiting step is also noted in the figure. **, all of the steps that may involve degradation. The vector DNA illustrated by dotted line represents lost AAV genomes.
