Table 1.
Growth of Mycobacterium tuberculosis and CD3+ CD4+ T cell subsets in the lungs of infected mice.
| Mtb lung CFU | Day 7 1 ± 0·1 × 103 | Day 14 1·8 ± 0·2 × 104 | Day 21 6·3 ± 1 × 105 | Day 28 3·1 ± 1 × 106 | Day 35 2·8 ± 0·8 × 106 |
|---|---|---|---|---|---|
| T cell subsets (%) | |||||
| CD3+ 4+ | 23 | 35 | 41 | 29 | 29 |
| CD3+ 4+ 25+ | n.d. | n.d. | 2 | 11 | 3 |
| CD3+ 4+ 25+ IFN+ | 0·2 | 3·7 | 2·0 | 8·6 | 2·9 |
| CD3+ 4+ 25+ TGFβ+ | 6·7 | 3·5 | 3·0 | 3·8 | 6·4 |
| CD3+ 4+ 25+ IL-10+ | 4·1 | 5·8 | 3·0 | 1·8 | 1·1 |
Data represent pooled cells from groups at each time-point. IFN: interferon; TGF: transforming growth factor; IL: interleukin; n.d.: not done; CFU: colony-forming units.