Table 2.
Comparison of serotype specific anti-pneumococcal antibody concentration, clinical and immunological data according to pre-immunization total anti-pneumococcal antibody concentration.
| Pre-immunization total anti-pneumococcal antibody concentration | |||
|---|---|---|---|
| < 11 AU/ml | ≥ 11 AU/ml | P-value | |
| Serotype concentrations | |||
| Serotype 14 | 0·87 (4) | 2·78 (4) | < 0·001 |
| Serotype 19F | 1·06 (3) | 2·99 (3) | < 0·001 |
| Serotype 23F | 0·39 (3) | 0·86 (3) | 0·001 |
| Clinical categories | |||
| Number of patients | 138 | 38 | |
| Median age, months (range) | 43 (17–204) | 66 (25–173) | < 0·001 |
| Otitis media | 83 (60) | 15 (39) | n.s. |
| Sinusitis | 16 (12) | 10 (26) | n.s. |
| URTI | 83 (60) | 17 (45) | n.s. |
| Pneumonia | 47 (34) | 9 (24) | n.s. |
| Ear tube placement | 44 (32) | 7 (18) | n.s. |
| Adenoidectomy | 57 (41) | 11 (29) | n.s. |
| Immunological categories | |||
| Number of patient | 97 | 29 | |
| IgA deficiency | 20 (21) | 7 (24) | n.s. |
| Ig 2 deficiency | 2 (2) | 1 (3) | n.s. |
| IgG3 deficiency | 10 (10) | 6 (21) | n.s. |
| IgA and/or IgG subclass deficiency | 27 (28) | 12 (41) | n.s. |
Specific serotype antibody concentrations are expressed as geometric means in µg/ml and standard deviation in brackets. Others values are expressed as numbers of patients and percentages in brackets. URTI = upper respiratory tract infection; n.s. = non-significant.