Table 2.
Immunological characteristics of common variable immunodeficiency (CVID) patients with high large granular lymphocyte (LGL) counts.
| CVID patients | High LGL counts1 (n = 12) | Normal LGL counts1 (n = 19) | Significance2 |
|---|---|---|---|
| CD4/CD8 T cell ratio | 0·48 (0·33–0·73) | 0·96 (0·73–1·58) | P= 0·001 |
| CD4+ T cells3 | 0·7 (0·55–1·83) | 0·5 (0·35–0·91) | P= 0·17 |
| CD8+ T cells3 | 1·7 (0·81–2·37) | 0·5 (0·28–0·94) | P= 0·004 |
| CD3+CD45RO+4 | 49 (42–63) | 49 (40–64) | P= 0·9 |
| CD4+CD45RO+5 | 31 (21–33) | 44 (29–52) | P= 0·017 |
| CD3+HLA-DR+4 | 53 (25–67) | 28 (17–48) | P= 0·09 |
| CD8+HLA-DR+6 | 23 (11–35) | 13 (3–20) | P= 0·044 |
| CCR7+4 | 32 (15–54) | 43 (36–69) | P= 0·08 |
1
Number of LGL > 0·32 109/l.
2
P-value determined using Mann–Whitney test.
3
Absolute number; 109/l.
4
Percentage of all T cells.
5
Percentage of all CD4+ T cells.
6
Percentage of all CD8+ T cells. HLA: human leucocyte antigen.