Table 1.
Genotype–phenotype correlation. Comparison table showing the correlation between the three genotypes of the −564 A/G promotor polymorphism in the proteinase 3 (PR3) gene and the four PR3 parameters, % of membrane-PR3 (mPR3)-positive cells, mean fluorescence intensity (MFI), expression index (EI) and plasma PR3 (median). (a) Shows the results of healthy blood donors. (b) Shows the results of patients with anti-neutrophil cytoplasm antibodies-associated systemic vasculitis.
| Genotype | % of positive cells | MFI | EI | Plasma PR3 |
|---|---|---|---|---|
| (a) | ||||
| AA | 45 | 1·61 | 54·8 | 185 |
| AG | 40 | 1·13 | 53·3 | 167 |
| GG | 45 | 1·13 | 50·3 | 130 |
| P | 0·98 | 0·57 | 0·79 | 0·0002 |
| n | 83 | 83 | 83 | 110 |
| (b) | ||||
| AA | 71 | 1·52 | 100 | 223 |
| AG | 65 | 1·42 | 109 | 199 |
| GG | 52 | 1·01 | 64·8 | 154 |
| P | 0·28 | 0·07 | 0·17 | 0·082 |
| n | 52 | 52 | 52 | 57 |