Table 2.
Frequencies of cytotoxic T lymphocyte antigen-4 (CTLA-4) −318 C/T and +49 A/G polymorphisms in systemic sclerosis (SSc) patients and in healthy controls.
| n (%) | n (frequency) | ||||||
|---|---|---|---|---|---|---|---|
| Genotypes | Patients (n = 43) | Controls (n = 93) | P | Alleles | Patients (2n = 86) | Controls (2n = 186) | P |
| −318 C/T | −318 C/T | ||||||
| C/C | 31 (72·1) | 71 (76·4) | 0·341 | C | 74 (0·86) | 161 (0·87) | 0·992 |
| C/T | 12 (27·9) | 19 (20·4) | T | 12 (0·14) | 25 (0·13) | ||
| T/T | 0 (0) | 3 (3·2) | |||||
| HWE | HWE | ||||||
| P = 0·29 | P = 0·24 | ||||||
| +49 A/G | +49 A/G | ||||||
| A/A | 18 (41·9) | 53 (57) | 0·221 | A | 59 (0·69) | 141 (0·76) | 0·242 |
| A/G | 23 (54·5) | 35 (37·6) | G | 27 (0·31) | 45 (0·24) | ||
| G/G | 2 (4·6) | 5 (5·4) | |||||
| HWE | HWE | ||||||
| P = 0·11 | P = 0·80 | ||||||
| Diplotypes −318 and +49 | Haplotypes −318 and +49 | ||||||
| CA/CA | 11 (25·6) | 36 (38·7) | 0·391 | −318C +49 A: CA | 47 (0·55) | 116 (0·62) | 0·421 |
| CA/CG | 18 (41·9) | 30 (32·3) | −318C +49 G: CG | 27 (0·31) | 45 (0·24) | ||
| CA/TA | 7 (16·3) | 14 (15·1) | − 318T +49 A: TA | 12 (0·14) | 25 (0·14) | ||
| CG/TA | 5 (11·6) | 5 (5·4) | |||||
| CG/CG | 2 (4·7) | 5 (5·4) | |||||
| TA/TA | 0 (0) | 3 (3·2) | |||||
| HWE | HWE | ||||||
| P = 0·33 | P = 0·67 | ||||||
HWE: Hardy–Weinberg equilibrium tested by Pearson's χ2 test (P < 0·05 indicates a lack of HWE).
1
χ2 test
2
Fisher's test.