Table 3.
Frequencies of cytotoxic T lymphocyte antigen-4 (CTLA-4) −318 C/T and +49 A/G polymorphisms in systemic sclerosis (SSc) patients according to anti-thyroperoxidase (TPO) and anti-thyroglobulin (TGA) status.
| n (%) | ||||
|---|---|---|---|---|
| CTLA-4 genotypes | HT− (n = 20) | HT+ (n = 20) | Controls (n = 93) | P1 |
| –318 C/T | ||||
| C/C | 11 (55%) | 18 (90%) | 71 (76·4%) | 0·060 |
| C/T | 9 (45%) | 2 (10%) | 19 (20·4%) | |
| T/T | 0 (0%) | 0 (0%) | 3 (3·2%) | |
| HWE | HWE | HWE | ||
| P = 0·19 | P = 0·81 | P = 0·24 | ||
| T-allele | ||||
| T− (C/C) | 11 (55%) | 18 (90%) | 71 (76·3%) | 0·034 |
| T+ (C/T, T/T) | 9 (45%) | 2 (10%) | 22 (23·7%) | |
| +49 A/G | ||||
| A/A | 6 (30%) | 9 (45%) | 53 (57%) | 0·23 |
| A/G | 13 (65%) | 10 (50%) | 35 (37·6%) | |
| G/G | 1 (5%) | 1 (5%) | 5 (5·4%) | |
| HWE | HWE | HWE | ||
| P = 0·08 | P = 0·39 | P = 0·80 | ||
| G-allele | ||||
| G− (A/A) | 6 (30%) | 9 (45%) | 53 (57%) | 0·076 |
| G+ (A/G, G/G) | 14 (70%) | 11 (55%) | 40 (43%) | |
HWE: Hardy–Weinberg equilibrium tested by Pearson's χ2 test (P < 0·05 indicates a lack of HWE).
1
χ2 test. HT−: SSc patients anti-TPO/TGA). HT+: SSc patients positive for anti-TPO/TGA.