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Interferon (IFN)-γ was produced abundantly in dextran sodium sulphate (DSS)-induced colitis. Wild-type (left) and IFN-γ knock-out (right) mice were treated with DSS for 7 days (closed bars) or left untreated (open bars). Colonic tissue was homogenized, and the resultant lysate was subjected to enzyme-linked immunosorbent assay to detect IFN-γ. Means ± s.d. of IFN-γ concentrations are shown (n = 6 in each group). *P < 0·01.
