Table 1.
Group characteristics and genotype frequencies for 5-HT1A SNPs in population of healthy Caucasian volunteers
|
Locus |
Genotype |
Frequency (n = 140) |
Percentage |
Hardy-Weinberg (p value) |
|---|---|---|---|---|
| (−1018)C/G | CC | 36 | 25.7 | 0.484 |
| CG | 74 | 52.9 | ||
| GG | 30 | 21.4 | ||
| +82A/G | AA | 137 | 97.9 | 0.898 |
| AG | 3 | 2.1 | ||
| GG | 0 | 0 | ||
| +549C/T | CC | 138 | 98.6 | 0.932 |
| CT | 2 | 1.4 | ||
| TT | 0 | 0 | ||
| +656G/T | GG | 135 | 96.4 | 0.830 |
| GT | 5 | 3.6 | ||
|
|
TT |
0 |
0 |
|
Genotype frequencies and percentages for 140 healthy Caucasian controls from the greater Oxfordshire, United Kingdom, region are listed. Genetic variation within this population was observed in only four of nine SNPs, for which Hardy-Weinberg equation values are indicated. Characteristics of the subjects are as follows: age, median of 51.7 years, range of 36.4-68 years; mean ± SD of 52.0 ± 8.8.