Table 4.
Interstitial volume (VI) – fraction of total extravascular water
| Species | Solute | Reference | Organ | VI | Comments |
| Rat | EDTA | [35,64,65] | sk. mus. | .081–091 | Renal ligature-sampled 30 minutes after death. |
| skin | .55–.73 | ||||
| tendon | .83 | ||||
| intestine | .28–.32 | ||||
| [66] | sk. mus | .12 | Renal ligature-samples from live rat. | ||
| skin | .63 | ||||
| [67]1 | sk. mus. | .075 | Constant infusion. Measured time course of tissue uptake. | ||
| skin | .52 | ||||
| intestine | .15–.25 | Muscle, stomach and intestine equilibrated in <40 minutes. | |||
| stomach | .23 | ||||
| adipose | .49 | ||||
| liver | .34 | ||||
| lung | .2 | ||||
| brain | ≈ 0 | ||||
| [50] | skin | .61 | Renal ligature – divided skin into dermis and sub-cutaneous samples. | ||
| dermis | .67 | ||||
| subcutis | .51 | ||||
| [68]1 | sk. mus | .15 | Constant infusion. Volume increased with time for skin and colon. Range indicates volume at 60 to 120 minutes | ||
| skin | .44–.63 | ||||
| sm. intestine | .29 | ||||
| colon | .3–.41 | ||||
| adipose | 1.0 | ||||
| Sulfate | [69]1 | skin | .65 | Nephrectomized | |
| muscle | .26 | ||||
| Mannitol | skin | .66 | |||
| muscle | .26 | ||||
| Sulfate | [70]1,2 | muscle | .12 | Nephrectomized | |
| Inulin | [9] | sk. mus. | .12 | Constant infusion. | |
| skin | .3 | ||||
| intestine | .12 | ||||
| liver | .2 | ||||
| lung | .27 | ||||
| [71]1 | sk. mus. | .1 | Constant infusion. Tissue uptake corresponds to capillary PS ≈ 0.6 ml/min/100 gm | ||
| Rabbit | EDTA | [72] | sk. mus | .077 | Renal ligature. |
| skin | .42 | ||||
| EDTA | [73]1,2 | sk. mus. | .10 | Renal ligature. Measured time course of tissue uptake. | |
| heart | .25 | ||||
| Sucrose | sk. mus. | .11 | Equilibrated in < 30 minutes. | ||
| heart | .25 | ||||
| Inulin | sk. mus. | .1 | |||
| heart | .24 | ||||
| [74] | sk. mus. | .09 | Renal ligature. Determined time constant T≈ 9 min. | ||
| heart | .28 | T ≈ 1 min. | |||
| intestine | .2 | T ≈ 1.5 min | |||
| ear | .5 | T ≈ 12 min | |||
| Cat | EDTA | [75] | sk. mus. | .13 | Renal ligature. |
| skin | .88 | ||||
| Dog | EDTA | [76] | sk. mus. | .16 | Renal ligature. |
| skin | .78 | ||||
| Sulfate | [70]1,2 | muscle | .20 | Constant infusion. Equilibration time <30 minutes. | |
| Sucrose | [49]1 | sk. mus. | .23 | Constant infusion. Cannulated prepopliteal lymphatic and measured lymph sucrose | |
| skin | .53 | ||||
| tendon | .67 | ||||
| Thiosulfate | [51]2 | muscle | .13 | Renal ligature. Equilibration time < 180 min. | |
| skin | .77 | Equilibration time < 180 min | |||
| tendon | .75 | Equilibration time ≥ 360 min. | |||
| Inulin | muscle | .1 | Equilibration time < 180 min. | ||
| skin | .48 | Equilibration time < 180 min | |||
| tendon | .26 | Equilibration time ≥ 360 min. | |||
| Man | Inulin1,2 | [77] | sk. mus. | .08–.11 | Bolus plus constant infusion. Tissue biopsy after 20 – 120 minutes. |