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Model for Skb1 function in S. pombe. Our results suggest that Skb1 is a component of the morphological control branch of the Ras1 signaling cascade in S. pombe and that it positively modulates Shk1 function. Genetic analyses suggest that Skb1 acts downstream from Ras1 and Scd2, at the same level as Cdc42, and upstream of Shk1. Question marks denote uncertainties in the Ras1-dependent signaling cascade. Shk1 and Cdc42 are essential for cell viability in S. pombe. See text for details.
